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Pursuing oral administration of radiolabeled zafirlukast to volunteers, urinary excretion accounts for about 10% in the dose and the remainder is excreted in feces. Zafirlukast isn't detected in urine.Zafirlukast is thoroughly hepatically metabolized by an enzyme referred to as CYP2C9. Zafirlukast inhibits the action of CYP3A4, leading to drug-drug